Article
Genetic variation in apolipoprotein E alters regional gray matter volumes in remitted late-onset depression.
Journal of affective disorders - 1 Mar 2010
Yuan Yonggui, Zhang Zhijun, Bai Feng, You Jiayong, Yu Hui, Shi Yongmei, Liu Wen
Abstract excerpt
BACKGROUND: The apolipoprotein E (ApoE) gene has been confirmed as the major genetic risk factor for late-onset Alzheimer's disease (AD). The effect of ApoE polymorphism on brain morphology still remains unclear in remitted late-onset depression (RLOD). METHODS: A total of 37 patients with remitted geriatric depression were investigated with optimized voxel-based morphometry. We tested for differences in gray...
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