Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele.

Neurology - 10 Oct 2006

Wishart H A, Saykin A J, McAllister T W, Rabin L A, McDonald B C, Flashman L A, Roth R M, Mamourian A C, Tsongalis G J, Rhodes C H

Abstract excerpt

OBJECTIVE: To determine whether cognitively intact adults with the APOE epsilon3/epsilon4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the epsilon3 allele. METHODS: Participants were healthy, cognitively intact, right-handed adults, age 19 to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Apolipoproteins E
Share to Atrophy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition Disorders

Share to DNA Mutational Analysis

Share to Magnetic Resonance Imaging

Share to Neurons

Source

Identifiers

PMID: 17030756
DOI: 10.1212/01.wnl.0000238079.00472.3a

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17030756-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele.PMID 17030756Read ↗

Regional atrophy of transcallosal prefrontal connections in cognitively normal APOE epsilon4 carriers.Semantic proximity Read ↗

No epsilon4 gene dose effect on hippocampal atrophy in a large MRI database of healthy elderly subjects.Semantic proximity Read ↗

Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E polymorphism and brain morphology in mild cognitive impairment.Semantic proximity Read ↗

Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon4 allele.Semantic proximity Read ↗

Impact of APOE-ε alleles on brain structure and cognitive function in healthy older adults: A VBM and DTI replication study.Semantic proximity Read ↗

Altered brain white matter integrity in healthy carriers of the <i>APOE</i> ε4 alleleSemantic proximity Read ↗

Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease.Semantic proximity Read ↗

Patterns of cortical thickness according to APOE genotype in Alzheimer's disease.Semantic proximity Read ↗

Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele.Semantic proximity Read ↗

Effects of ApoE-epsilon4 allele load and age on the rates of grey matter and hippocampal volumes loss in a longitudinal cohort of 1186 healthy elderly persons.Semantic proximity Read ↗

Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.