Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon4 allele.

doi:10.1136/jnnp.65.3.322

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Article

Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon4 allele.

Journal of neurology, neurosurgery, and psychiatry - 1 Sept 1998

Juottonen K, Lehtovirta M, Helisalmi S, Riekkinen P J, Soininen H

Abstract excerpt

OBJECTIVE: Recent evidence indicates that the apolipoprotein E (ApoE) epsilon4 allele is a risk factor for developing Alzheimer's disease. It has also been proposed that it is associated with increased counts of amyloid plaques and neurofibrillary tangles that in turn are neuropathological hallma...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Entorhinal Cortex
Female
Genetic Carrier Screening
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests

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Identifiers

PMID: 9728943
DOI: 10.1136/jnnp.65.3.322
PMCID: PMC2170244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9728943-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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