Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon4 allele.

Journal of neurology, neurosurgery, and psychiatry - 1 Sept 1998

Juottonen K, Lehtovirta M, Helisalmi S, Riekkinen P J, Soininen H

Abstract excerpt

OBJECTIVE: Recent evidence indicates that the apolipoprotein E (ApoE) epsilon4 allele is a risk factor for developing Alzheimer's disease. It has also been proposed that it is associated with increased counts of amyloid plaques and neurofibrillary tangles that in turn are neuropathological hallmarks initially appearing in the medial temporal lobe structures in Alzheimer's disease. In this study, the effect of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Alleles

Share to Alzheimer Disease

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Genetic Carrier Screening

Share to Magnetic Resonance Imaging

Source

Open in PubMed Open full text

Identifiers

PMID: 9728943
DOI: 10.1136/jnnp.65.3.322
PMCID: PMC2170244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon4 allele.PMID 9728943Read ↗

Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease.Semantic proximity Read ↗

APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD.Semantic proximity Read ↗

Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease.Semantic proximity Read ↗

Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele.Semantic proximity Read ↗

SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele.Semantic proximity Read ↗

No epsilon4 gene dose effect on hippocampal atrophy in a large MRI database of healthy elderly subjects.Semantic proximity Read ↗

Effects of ApoE-epsilon4 allele load and age on the rates of grey matter and hippocampal volumes loss in a longitudinal cohort of 1186 healthy elderly persons.Semantic proximity Read ↗

Apolipoprotein E epsilon 4 allele and whole brain atrophy in late-onset Alzheimer's disease.Semantic proximity Read ↗

Regional atrophy of transcallosal prefrontal connections in cognitively normal APOE epsilon4 carriers.Semantic proximity Read ↗

Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.Semantic proximity Read ↗

Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study.Semantic proximity Read ↗

Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.