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Article

Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population.

Carcinogenesis - 1 Oct 2009

Imaizumi Takeshi, Higaki Yasuki, Hara Megumi, Sakamoto Tatsuhiko, Horita Mikako, Mizuta Toshihiko, Eguchi Yuichiro, Yasutake Tsutomu, Ozaki Iwata, Yamamoto Kyosuke, Onohara Shingo, Kawazoe Seiji, Shigematsu Hirohisa, Koizumi Shunzo, Kudo Sho, Tanaka Keitaro

Abstract excerpt

Limited epidemiological evidence suggests that genetic polymorphisms of drug-metabolizing enzymes such as cytochrome P450 (CYP), glutathione S-transferase (GST) and N-acetyltransferase (NAT) may be involved in tobacco-related hepatocarcinogenesis. We conducted a case-control study, including 209 incident cases with hepatocellular carcinoma (HCC) and two different control groups [275 hospital controls and 381...

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Source

Identifiers

PMID: 19643819
DOI: 10.1093/carcin/bgp191

Genes

GSTM1
NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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