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Article

Common genetic variations of the cytochrome P450 1A1 gene and risk of hepatocellular carcinoma in a Chinese population.

European journal of cancer (Oxford, England : 1990) - 1 May 2009

Li Rui, Shugart Yin Yao, Zhou Weiping, An Yu, Yang Yuan, Zhou Yun, Zhang Beibei, Lu Daru, Wang Hongyang, Qian Ji, Jin Li

Abstract excerpt

Cytochrome P450 1A1 is a major enzyme in the bioactivation of exogenous procarcinogens of hepatocellular carcinoma (HCC). However, the contribution of common genetic variants in CYP1A1 to the HCC risk in Chinese populations has not been thoroughly investigated. In this study, we examined the association between HCC and four selected tagging single nucleotide polymorphisms (SNPs) of CYP1A1, and the risk of CYP1A1...

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PMID: 19110417
DOI: 10.1016/j.ejca.2008.11.007

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