Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of metallothionein-1 genetic polymorphism and cigarette smoking on the development of hepatocellular carcinoma.

Annals of surgical oncology - 1 Jun 2013

Wong Ruey-Hong, Huang Chun-Huang, Yeh Chao-Bin, Lee Hong-Shen, Chien Ming-Hsien, Yang Shun-Fa

Abstract excerpt

BACKGROUND: A low expression of metallothionein (MT) has been observed in liver cancer. Such a phenomenon might be influenced by oxidative stress, thus resulting in the cells being more susceptible to DNA damage and apoptotic death. In particular, oxidative stress induced by cigarette smoking might affect MT-1 expression. We designed a hospital-based case-control study to evaluate the effects of MT-1 genotypes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Haplotypes

Share to Liver Neoplasms

Share to Metallothionein

Share to Oxidative Stress

Share to Risk Factors

Share to Smoking

Source

Identifiers

PMID: 22805858
DOI: 10.1245/s10434-012-2456-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of metallothionein-1 genetic polymorphism and cigarette smoking on the development of hepatocellular carcinoma.PMID 22805858Read ↗

The rs3957357C>T SNP in GSTA1 Is Associated with a Higher Risk of Occurrence of Hepatocellular Carcinoma in European Individuals.Semantic proximity Read ↗

Polymorphisms of the CYP1B1 gene and hepatocellular carcinoma risk in a Chinese population.Semantic proximity Read ↗

Common genetic variations of the cytochrome P450 1A1 gene and risk of hepatocellular carcinoma in a Chinese population.Semantic proximity Read ↗

<i>MT1M</i>and<i>MT1G</i>promoter methylation as biomarkers for hepatocellular carcinomaSemantic proximity Read ↗

Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomasSemantic proximity Read ↗

Association between methylenetetrahydrofolate reductase tagging polymorphisms and susceptibility of hepatocellular carcinoma: a case-control study.Semantic proximity Read ↗

Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review.Semantic proximity Read ↗

Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma.Semantic proximity Read ↗

MMP-2 rs243865 Polymorphism as a Risk Modifier of Hepatocellular Carcinoma in Taiwanese Males, Smokers and Alcohol Consumers.Semantic proximity Read ↗

Association of CYP1A2 genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a high-risk region of China.Semantic proximity Read ↗

Molecular Links between Alcohol and Tobacco Induced DNA Damage, Gene Polymorphisms and Patho-physiological Consequences: A Systematic Review of Hepatic Carcinogenesis.Semantic proximity Read ↗

Revisiting the metallothionein genes polymorphisms and the risk of oral squamous cell carcinoma in a Brazilian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.