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Article

Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma.

Journal of cancer research and clinical oncology - 1 Jun 2003

Munaka Masahiro, Kohshi Kiyotaka, Kawamoto Toshihiro, Takasawa Shin, Nagata Naoki, Itoh Hideaki, Oda Susumu, Katoh Takahiko

Abstract excerpt

The effect of genetic polymorphisms for glutathione S-transferase ( GST) M1, GSTT1, GSTP1-1( GSTP1), cytochrome P450 2E1 ( CYP2E1) and aldehyde dehydrogenase 2 ( ALDH2) on the risk of hepatocellular carcinoma (HCC) was observed in 78 Japanese patients with HCC and 138 non-cancer hospital controls. We found a positive association between cumulative amounts of alcohol consumption (>/=600,000 ml in a lifetime) and...

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Source

Identifiers

PMID: 12759747
DOI: 10.1007/s00432-003-0439-5

Genes

GSTP1
GSTT1
ALDH2
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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