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Article

Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo.

Blood - 1 Jul 2002

Gui Tong, Lin Hui-Feng, Jin Da-Yun, Hoffman Maureane, Straight David L, Roberts Harold R, Stafford Darrel W

Abstract excerpt

Residue K5 in factor IX gamma-carboxyglutamic acid (Gla) domain participates in binding endothelial cells/collagen IV. We injected recombinant factor IX containing mutations at residue 5 (K5A, K5R) into factor IX-deficient mice and compared their behavior with that of wild-type factor IX. The plasma concentration of factor IX that binds to endothelial cells/collagen IV (recombinant wild type and K5R) was...

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Identifiers

PMID: 12070021
DOI: 10.1182/blood.v100.1.153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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