Article
Polymorphism of Antifolate Drug Resistance in Plasmodium vivax From Local Residents and Migrant Workers Returned From the China-Myanmar Border.
Frontiers in cellular and infection microbiology - 1 Jan 2021
Zeng Weilin, Wang Siqi, Feng Shi, Zhong Daibin, Hu Yue, Bai Yao, Ruan Yonghua, Si Yu, Zhao Hui, Yang Qi, Li Xinxin, Chen Xi, Zhang Yanmei, Li Cuiying, Xiang Zheng, Wu Yanrui, Chen Fang, Su Pincan, Rosenthal Benjamin M, Yang Zhaoqing
Abstract excerpt
Drug-resistant Plasmodium vivax malaria impedes efforts to control, eliminate, and ultimately eradicate malaria in Southeast Asia. P. vivax resistance to antifolate drugs derives from point mutations in specific parasite genes, including the dihydropteroate synthase (pvdhps), dihydrofolate reductase (pvdhfr), and GTP cyclohydrolase I (pvgch1) genes. This study aims to investigate the prevalence and spread of drug...
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