Article
Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine.
European journal of biochemistry - 1 Sept 1994
Brooks D R, Wang P, Read M, Watkins W M, Sims P F, Hyde J E
Abstract excerpt
Dihydropteroate synthase (H2Pte synthase) is the target of the sulfur-based antimalarial drugs, which are frequently used in synergistic combination with inhibitors of dihydrofolate reductase (H2folate reductase) to combat chloroquine-resistant malaria. We have isolated the H2Pte synthase coding...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Consensus Sequence
- DNA Primers
- DNA, Protozoan
- Dihydropteroate Synthase
- Diphosphotransferases
- Drug Resistance
- Genetic Variation
- Humans
- Malaria, Falciparum
- Molecular Sequence Data