Article
Different allele prevalence in the dihydrofolate reductase and dihydropteroate synthase genes in Plasmodium vivax populations from China.
The American journal of tropical medicine and hygiene - 1 Dec 2010
Miao Miao, Yang Zhaoqing, Cui Long, Ahlum Jessica, Huang Yaming, Cui Liwang
Abstract excerpt
Antifolate resistance in Plasmodium vivax is caused by point mutations in genes encoding dihydrofolate reductase (pvdhfr) and dihydropteroate synthase (pvdhps). In this study, we used direct sequencing to survey pvdhfr and pvdhps mutations in 122 clinical P. vivax isolates from a central and a southern province of China. For pvdhfr, 36.9% were wild-type, whereas mutations were detected at four codons (57, 58, 61,...
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