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Article

Multiplexed tracking of combinatorial genomic mutations in engineered cell populations.

Nature biotechnology - 1 Jun 2015

Zeitoun Ramsey I, Garst Andrew D, Degen George D, Pines Gur, Mansell Thomas J, Glebes Tirzah Y, Boyle Nanette R, Gill Ryan T

Abstract excerpt

Multiplexed genome engineering approaches can be used to generate targeted genetic diversity in cell populations on laboratory timescales, but methods to track mutations and link them to phenotypes have been lacking. We present an approach for tracking combinatorial engineered libraries (TRACE) through the simultaneous mapping of millions of combinatorially engineered genomes at single-cell resolution. Distal...

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PMID: 25798935
DOI: 10.1038/nbt.3177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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