Article

Functional investigation of conserved glutamate receptor subunits reveals a new mode of action of macrocyclic lactones in nematodes

2020-12-17

Abstract excerpt

Glutamate-gated chloride channels receptors (GluCls) are involved in the inhibition of neurotransmission in invertebrates and represent major molecular targets for therapeutic drugs. Among these drugs, macrocyclic lactones (MLs) are widely used as anthelmintic to treat parasitic nematodes impacting both human and animal health. Despite massive use of MLs since the 80’s, the exact molecular targets of these drugs a...

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Literature Corpus work: 41019aed-8c52-50a8-a8ff-c2bd5201dc91
DOI: 10.1101/2020.12.17.423223

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