Article

Two novel loci underlie natural differences in <i>Caenorhabditis elegans</i> macrocyclic lactone responses

2021-01-14

Abstract excerpt

Parasitic nematodes cause a massive worldwide burden on human health along with a loss of livestock and agriculture productivity. Anthelmintics have been widely successful in treating parasitic nematodes. However, resistance is increasing, and little is known about the molecular and genetic causes of resistance. The free-living roundworm Caenorhabditis elegans provides a tractable model to identify genes that und...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: efbf7aab-82f8-5ecf-b8e3-b612997513b6
DOI: 10.1101/2021.01.14.426644

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Two novel loci underlie natural differences in <i>Caenorhabditis elegans</i> macrocyclic lactone responsesDOI 10.1101/2021.01.14.426644Read

Variation in anthelmintic responses are driven by genetic differences among diverse <i>C. elegans</i> wild strainsSemantic proximity Read

Discovery of unique loci that underlie nematode responses to benzimidazolesSemantic proximity Read

Mapping resistance-associated anthelmintic interactions in the model nematode <i>Caenorhabditis elegans</i>Semantic proximity Read

Discovery of genomic intervals that underlie nematode responses to benzimidazoles.Semantic proximity Read

Extreme allelic heterogeneity at a <i>Caenorhabditis elegans</i> beta-tubulin locus explains natural resistance to benzimidazolesSemantic proximity Read

Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles.Semantic proximity Read

A nematode-specific gene underlies bleomycin-response variation in <i>Caenorhabditis elegans</i>Semantic proximity Read

Praziquantel inhibits <i>Caenorhabditis elegans</i> development and species-wide differences might be cct-8-dependentSemantic proximity Read

Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic ActivitySemantic proximity Read

Genomic landscape of drug response reveals novel mediators of anthelmintic resistanceSemantic proximity Read

Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin allelesSemantic proximity Read

Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles.Semantic proximity Read