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Article

Acquired Tolerance to Ivermectin and Moxidectin after Drug Selection Pressure in the Nematode Caenorhabditis elegans.

Antimicrobial agents and chemotherapy - 1 Aug 2016

Ménez Cécile, Alberich Mélanie, Kansoh Dalia, Blanchard Alexandra, Lespine Anne

Abstract excerpt

Ivermectin and moxidectin are the most widely administered anthelmintic macrocyclic lactones (MLs) to treat human and animal nematode infections. Their widespread and frequent use has led to a high level of resistance to these drugs. Although they have the same mode of action, differences in terms of selection for drug resistance have been reported. Our objective was to study and compare changes occurring upon...

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PMID: 27246778
DOI: 10.1128/AAC.00713-16
PMCID: PMC4958191

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