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Article

Anthelmintic drug actions in resistant and susceptible C. elegans revealed by electrophysiological recordings in a multichannel microfluidic device.

International journal for parasitology. Drugs and drug resistance - 1 Dec 2018

Weeks Janis C, Robinson Kristin J, Lockery Shawn R, Roberts William M

Abstract excerpt

Many anthelmintic drugs used to treat parasitic nematode infections target proteins that regulate electrical activity of neurons and muscles: ion channels (ICs) and neurotransmitter receptors (NTRs). Perturbation of IC/NTR function disrupts worm behavior and can lead to paralysis, starvation, immune attack and expulsion. Limitations of current anthelmintics include a limited spectrum of activity across species...

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Identifiers

PMID: 30503202
DOI: 10.1016/j.ijpddr.2018.10.003
PMCID: PMC6287544

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