Back to search

Article

Unveiling mode of action of anthelmintics in <i>Caenorhabditis elegans</i> with SydLab™, an on-a-chip automated and high-content screening system

2025-05-19

Abstract excerpt

Anthelmintic resistance in parasitic nematodes presents a growing challenge to animal and human health, driving the need for innovative tools to accelerate drug discovery and mechanistic research. Here, we introduce SydLab™, a microfluidic-based, automated phenotypic screening platform that combines continuous imaging, machine vision, and computational analysis for high-content assessment of Caenorhabditis elegan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7228b960-6db9-529b-a377-4686f8e557bb
DOI
10.1101/2025.05.15.654210
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Unveiling mode of action of anthelmintics in <i>Caenorhabditis elegans</i> with SydLab™, an on-a-chip automated and high-content screening systemDOI 10.1101/2025.05.15.654210
Anthelmintic drug actions in resistant and susceptible C. elegans revealed by electrophysiological recordings in a multichannel microfluidic device.Semantic proximity
Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms.Semantic proximity
Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegansSemantic proximity
Deep phenotypic profiling uncovers cryptic effects of antifilarial drugsSemantic proximity
Deep phenotypic profiling uncovers cryptic effects of antifilarial drugs.Semantic proximity
Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans.Semantic proximity
<i>In vivo</i> quantitative high-throughput screening for drug discovery and comparative toxicologySemantic proximity
Mapping resistance-associated anthelmintic interactions in the model nematode <i>Caenorhabditis elegans</i>Semantic proximity
Leveraging Machine Learning in <em>Caenorhabditis elegans</em> Developmental StudiesSemantic proximity
wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms.Semantic proximity
Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance.Semantic proximity
A microfluidic platform for lifelong high-resolution and high throughput imaging of subtle aging phenotypes in C. elegans.Semantic proximity
Select a neighboring publication to make it the new centre.