Article
Multiple sclerosis risk: interaction between human leukocyte antigen and the environment in Sardinian population.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Sept 2009
Cocco E, Sardu C, Murru R, Frau J, Lorefice L, Mamusa E, Contu P, Marrosu M G
Abstract excerpt
BACKGROUND: The island of Sardinia features a high incidence of multiple sclerosis (MS) characterized by early age at onset and a progressively increasing trend. The current study was aimed at examining variations in human leukocyte antigen-risk genotypes occurring over time in a cohort of patients. METHODS: Susceptible and neutral DRB1-DQB1 genotypes were identified in 1660 patients. Age at onset was established...
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