Article
Genetic factors and the founder effect explain familial MS in Sardinia.
Neurology - 22 Jan 2002
Marrosu M G, Lai M, Cocco E, Loi V, Spinicci G, Pischedda M P, Massole S, Marrosu G, Contu P
Abstract excerpt
OBJECTIVE: To estimate the presence of familial aggregation and determine the contribution of genetic factors to familial clustering of MS in patients coming from Sardinia, a Mediterranean island considered a genetically homogeneous, isolated area having high disease incidence and prevalence. METHODS: Recurrence risk in siblings of 901 Sardinian patients and factors influencing risk (patient and sibling sex,...
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