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Advances in ligase chain reaction and ligation-based amplifications for genotyping assays: Detection and applications.

Mutation research. Reviews in mutation research - 1 Jul 2017

Gibriel Abdullah A, Adel Ola

Abstract excerpt

Genetic variants have been reported to cause several genetic diseases. Various genotyping assays have been developed for diagnostic and screening purposes but with certain limitations in sensitivity, specificity, cost effectiveness and/or time savings. Since the discovery of ligase chain reaction (LCR) in the late nineties, it became one of the most favored platforms for detecting these variants and also for...

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Identifiers

PMID: 28927538
DOI: 10.1016/j.mrrev.2017.05.001
PMCID: PMC7108312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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