Article
Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments.
PloS one - 1 Jan 2016
Yoshikawa Fumio, Sato Yumi, Tohyama Koujiro, Akagi Takumi, Furuse Tamio, Sadakata Tetsushi, Tanaka Mika, Shinoda Yo, Hashikawa Tsutomu, Itohara Shigeyoshi, Sano Yoshitake, Ghandour M Said, Wakana Shigeharu, Furuichi Teiichi
Abstract excerpt
Opalin, a central nervous system-specific myelin protein phylogenetically unique to mammals, has been suggested to play a role in mammalian-specific myelin. To elucidate the role of Opalin in mammalian myelin, we disrupted the Opalin gene in mice and analyzed the impacts on myelination and behavior. Opalin-knockout (Opalin-/-) mice were born at a Mendelian ratio and had a normal body shape and weight....
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