Article

Unaltered prion disease in mice lacking developmental endothelial locus-1 (Del-1)

2018-06-15

Abstract excerpt

Progression of prion diseases is driven by the accumulation of prions in the brain. Ablation of microglia or deletion of the eat-me-signal milk-fat globule EGF factor VIII (Mfge8) accelerate prion pathogenesis, suggesting that microglia defends the brain by phagocytosing prions. Like Mfge8, Developmental endothelial locus-1 (Del-1) is a secreted protein that acts as an opsonin bridging phagocytes and apoptotic cel...

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Literature Corpus work: 9c8affee-109a-536e-a242-213193b8864e
DOI: 10.1101/348177

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