Back to search

Article

Transcriptome network analysis link perinatal <i>Staphylococcus epidermidis</i> infection to microglia reprogramming in the immature hippocampus

2022-07-04

Abstract excerpt

Staphylococcus epidermidis ( S. epidermidis ) is the most common nosocomial pathogen in preterm infants and associated with increased risk of cognitive delay, however, underlying mechanisms are unknown. We employed morphological, transcriptomic and physiological methods to extensively characterize microglia in the immature hippocampus following S. epidermidis infection. 3D morphological analysis revealed activat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
22886eb0-b5ea-5bad-8acd-e4ecf98e966e
DOI
10.1101/2022.07.04.498695
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Transcriptome network analysis link perinatal <i>Staphylococcus epidermidis</i> infection to microglia reprogramming in the immature hippocampusDOI 10.1101/2022.07.04.498695
Germ-free piglets display variable neuroinflammatory-like perturbations in prefrontal cortical microgliaSemantic proximity
Retinal scRNAseq reveals cell-type-specific responses to bacterial infectionSemantic proximity
Look Who’s Talking: Host and Pathogen Drivers of Staphylococcus epidermidis Virulence in Neonatal SepsisSemantic proximity
“Integrative genomics study of microglial transcriptome reveals effect of DLG4 (PSD95) on white matter in preterm infants”Semantic proximity
Meningeal γδ T cells facilitate bacterial entry into the brain in neonatal meningitis and trigger long-term behavioural sequelaeSemantic proximity
Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zoneSemantic proximity
The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2-deficient leukoencephalopathy.Semantic proximity
Reduced glucose supply during neonatal infection attenuates neurological and renal pathology via modulation of innate and Th1 immunitySemantic proximity
Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infantsSemantic proximity
A Mechanism for Neurodegeneration Induced by Group B Streptococci through Activation of the TLR2/MyD88 Pathway in MicrogliaSemantic proximity
A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematuritySemantic proximity
Perivascular SPP1 Mediates Microglial Engulfment of Synapses in Alzheimer’s Disease ModelsSemantic proximity
Select a neighboring publication to make it the new centre.