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Article

Catechol-O-methyltransferase val158met genotype influences neural processing of reward anticipation.

NeuroImage - 1 Oct 2008

Schmack Katharina, Schlagenhauf Florian, Sterzer Philipp, Wrase Jana, Beck Anne, Dembler Theresa, Kalus Peter, Puls Imke, Sander Thomas, Heinz Andreas, Gallinat Jürgen

Abstract excerpt

Reward processing depends critically on dopaminergic neurotransmission in the ventral striatum. The common polymorphism val(158)met of catechol-O-methyltransferase (COMT) accounts for significant interindividual variations in dopamine (DA) degradation, although the direct effect of COMT on striatal DA might be limited. Using fMRI we assessed the influence of COMT val(158)met genotype on brain activations elicited...

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Source

Identifiers

PMID: 18634888
DOI: 10.1016/j.neuroimage.2008.06.019

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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