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Article

Polymorphisms of COMT and CREB1 are associated with treatment-resistant depression in a Chinese Han population.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2022

Wang Yuting, Li Shen, Niu Lichao, Ma Yanyan, Qiu Yuying, Li Shuhua, Guobule Nanage, Cao Haiyan, Li Jie

Abstract excerpt

Genetic factors play a crucial role for the pathophysiology of treatment-resistant depression (TRD). It has been established that Catechol-O-methyltransferase (COMT) and cyclic amp-response element-binding protein (CREB) are associated with antidepressant response. The aim of this study was to explore the association between single nucleotide polymorphisms (SNPs) in COMT and CREB1 genes and TRD in a Chinese...

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PMID: 34767111
DOI: 10.1007/s00702-021-02415-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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