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Article

Altered reward processing in the orbitofrontal cortex and hippocampus in healthy first-degree relatives of patients with depression.

Psychological medicine - 1 Apr 2014

Macoveanu J, Knorr U, Skimminge A, Søndergaard M G, Jørgensen A, Fauerholdt-Jepsen M, Paulson O B, Knudsen G M, Siebner H R, Kessing L V

Abstract excerpt

BACKGROUND: Healthy first-degree relatives of patients with major depression (rMD+) show brain structure and functional response anomalies and have elevated risk for developing depression, a disorder linked to abnormal serotonergic neurotransmission and reward processing. METHOD: In a two-step fu...

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PMID: 23866315
DOI: 10.1017/S0033291713001815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23866315-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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