Article
Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension.
Croatian medical journal - 1 Oct 2008
Bilusić Marijo, Moreno Carol, Barreto Nadia E, Tschannen Michael R, Harris Eugenie L, Porteous William K, Thompson Caryn M, Grigor Murray R, Weder Alan, Boerwinkle Eric, Hunt Steven C, Curb J David, Jacob Howard J, Kwitek Anne E
Abstract excerpt
AIM: To determine the independent and combined effects of three quantitative trait loci (QTL) for blood pressure in the Genetically Hypertensive (GH/Omr) rat by generating and characterizing single and combined congenic strains that have QTL on rat chromosomes (RNO) 2, 6, and 18 from the GH rat introduced into a hypertension resistant Brown Norway (BN) background. METHODS: Linkage analysis and QTL identification...
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