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Article

GABA(A) receptor membrane trafficking regulates spine maturity.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2009

Jacob Tija C, Wan Qin, Vithlani Mansi, Saliba Richard S, Succol Francesca, Pangalos Menelas N, Moss Stephen J

Abstract excerpt

GABA(A) receptors (GABA(A)Rs), the principal sites of synaptic inhibition in the brain, are dynamic entities on the neuronal cell surface, but the role their membrane trafficking plays in shaping neuronal activity remains obscure. Here, we examined this by using mutant receptor beta3 subunits (beta3S408/9A), which have reduced binding to the clathrin adaptor protein-2, a critical regulator of GABA(A)R...

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Identifiers

PMID: 19617557
DOI: 10.1073/pnas.0903943106
PMCID: PMC2718332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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