Article
Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor.
The Journal of cell biology - 25 Oct 2004
Nakatsu Fubito, Okada Motohiro, Mori Fumiaki, Kumazawa Noriko, Iwasa Hiroto, Zhu Gang, Kasagi Yasufumi, Kamiya Haruyuki, Harada Akihiro, Nishimura Kazuhiro, Takeuchi Arata, Miyazaki Taisuke, Watanabe Masahiko, Yuasa Shigeki, Manabe Toshiya, Wakabayashi Koichi, Kaneko Sunao, Saito Takashi, Ohno Hiroshi
Abstract excerpt
AP-3 is a member of the adaptor protein (AP) complex family that regulates the vesicular transport of cargo proteins in the secretory and endocytic pathways. There are two isoforms of AP-3: the ubiquitously expressed AP-3A and the neuron-specific AP-3B. Although the physiological role of AP-3A has recently been elucidated, that of AP-3B remains unsolved. To address this question, we generated mice lacking mu3B, a...
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