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Article

Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1.

Nature neuroscience - 1 May 2006

Pérez-Otaño Isabel, Luján Rafael, Tavalin Steven J, Plomann Markus, Modregger Jan, Liu Xiao-Bo, Jones Edward G, Heinemann Stephen F, Lo Donald C, Ehlers Michael D

Abstract excerpt

A key step in glutamatergic synapse maturation is the replacement of developmentally expressed N-methyl-D-aspartate receptors (NMDARs) with mature forms that differ in subunit composition, electrophysiological properties and propensity to elicit synaptic plasticity. However, the mechanisms underlying the removal and replacement of synaptic NMDARs are poorly understood. Here we demonstrate that NMDARs containing...

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Source

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Identifiers

PMID: 16617342
DOI: 10.1038/nn1680
PMCID: PMC1892311

Genes

PACSIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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