Article
Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 2015
Vien Thuy N, Modgil Amit, Abramian Armen M, Jurd Rachel, Walker Joshua, Brandon Nicholas J, Terunuma Miho, Rudolph Uwe, Maguire Jamie, Davies Paul A, Moss Stephen J
Abstract excerpt
Alterations in the efficacy of neuronal inhibition mediated by GABAA receptors (GABAARs) containing β3 subunits are continually implicated in autism spectrum disorders (ASDs). In vitro, the plasma membrane stability of GABAARs is potentiated via phosphorylation of serine residues 408 and 409 (S408/9) in the β3 subunit, an effect that is mimicked by their mutation to alanines. To assess if modifications in β3...
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