p53 from basic research to clinical applications.

Article

p53 from basic research to clinical applications.

Critical reviews in oncogenesis - 1 Jan 1992

Tominaga O, Hamelin R, Remvikos Y, Salmon R J, Thomas G

Abstract excerpt

Mutations on the TP53 tumor suppressor gene and allele loss on chromosome 17p, where this gene has been located, are among the most frequent alterations yet identified in human malignancies. The p53 protein is highly conserved through evolution and expressed in most normal tissues. Wild-type p53...

Topics

Animals
Cell Transformation, Neoplastic
Genes, Retinoblastoma
Genes, p53
Humans
Mutation
Neoplasms
Prognosis
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.