Article
Rearrangements of immunoglobulin light and heavy chain genes and correlation with phenotypic markers in B-cell chronic lymphocytic leukemia.
Leukemia - 1 Nov 1991
Lenormand B, Ghanem N, Tilly H, Boussemart C, Monconduit M, Piguet H, Lefranc G, Lefranc M P
Abstract excerpt
Twenty-five patients with B-cell chronic lymphocytic leukemia (B-CLL) were investigated to correlate the immunological phenotype with the description of the Ig gene rearrangements of the B-cell clone. All patients were positive for the CD19 antigen and one pan B-antigen, markers of late cells (CD20, CD37 or Y2955). Twenty-four of the 25 patients tested expressed monoclonal cell surface immunoglobulin (SIg). The...
Topics
- B-Lymphocytes
- Blotting, Southern
- Fluorescent Antibody Technique
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Leukemia, Lymphocytic, Chronic, B-Cell
- Middle Aged