Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Southern blot detection of immunoglobulin lambda light chain gene rearrangements for clonality studies.

Leukemia - 1 Dec 1995

Tümkaya T, Comans-Bitter W M, Verhoeven M A, van Dongen J J

Abstract excerpt

Southern blot analysis of immunoglobulin (Ig) genes has proven to be important for detection of clonal rearrangements in patients with lymphoproliferative diseases. To improve the detection of clonal Ig lambda (Ig lambda) gene rearrangements, we carefully determined the precise restriction map of the J-C lambda gene region, developed a suitable C lambda probe (IGLC3), and evaluated relevant restriction enzymes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to Blotting, Southern

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte

Share to Immunoglobulin lambda-Chains

Share to Immunoglobulin Light Chains

Share to Lymphoma, B-Cell

Share to Molecular Sequence Data

Source

Identifiers

PMID: 8609728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Southern blot detection of immunoglobulin lambda light chain gene rearrangements for clonality studies.PMID 8609728Read ↗

Ig gene sequences in the study of clonality.Semantic proximity Read ↗

T cell receptor and immunoglobulin gene rearrangement analysis as a laboratory aid in the diagnosis of human malignant lymphoproliferative diseases.Semantic proximity Read ↗

Automated high resolution PCR fragment analysis for identification of clonally rearranged immunoglobulin heavy chain genes.Semantic proximity Read ↗

Distinguishing between monoclonal rearrangements and allelic forms of the immunoglobulin lambda light chain constant region genes. Significance in the diagnosis of non-Hodgkin's lymphoma.Semantic proximity Read ↗

Richter's syndrome with different immunoglobulin light chain types. Molecular and cytogenetic features indicate a common clonal origin.Semantic proximity Read ↗

Molecular immunoglobulin/T-cell receptor clonality diagnosis by gene scan in lymphoproliferative disorders.Semantic proximity Read ↗

Characterization of the human Ig V lambda II gene family and analysis of V lambda II and C lambda polymorphism in systemic lupus erythematosus.Semantic proximity Read ↗

Rapid Molecular Cloning of Rearrangements of the IGHJ Locus Using Long-Distance Inverse Polymerase Chain ReactionSemantic proximity Read ↗

Rearrangements of immunoglobulin light and heavy chain genes and correlation with phenotypic markers in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

Description of a novel FR1 IgH PCR strategy and its comparison with three other strategies for the detection of clonality in B cell malignancies.Semantic proximity Read ↗

Genomic EcoRI polymorphism and cosmid sequencing reveal an insertion/deletion and a new IGLV5 allele in the human immunoglobulin lambda variable locus (22q11.2/IGLV).Semantic proximity Read ↗

PCR Techniques for Clonality AssaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.