Southern blot detection of immunoglobulin lambda light chain gene rearrangements for clonality studies.

Article

Southern blot detection of immunoglobulin lambda light chain gene rearrangements for clonality studies.

Leukemia - 1 Dec 1995

Tümkaya T, Comans-Bitter W M, Verhoeven M A, van Dongen J J

Abstract excerpt

Southern blot analysis of immunoglobulin (Ig) genes has proven to be important for detection of clonal rearrangements in patients with lymphoproliferative diseases. To improve the detection of clonal Ig lambda (Ig lambda) gene rearrangements, we carefully determined the precise restriction map of...

Topics

Alleles
Base Sequence
Blotting, Southern
Gene Rearrangement, B-Lymphocyte
Humans
Immunoglobulin Light Chains
Immunoglobulin lambda-Chains
Lymphoma, B-Cell
Molecular Sequence Data

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