Article
Oncogene rearrangements in chronic B-cell leukemia.
Blood - 1 Apr 1991
Raghoebier S, van Krieken J H, Kluin-Nelemans J C, Gillis A, van Ommen G J, Ginsberg A M, Raffeld M, Kluin P M
Abstract excerpt
Forty-four B-chronic lymphocytic leukemias (CLL) were studied by Southern blot analysis using probes for the Ig genes and bcl-1, bcl-2 (major, minor and 5' breakpoint region), bcl-3, c-myc, and retinoblastoma (Rb) loci. Eight cases had three or more rearranged JH bands, indicating oligoclonality, clonal evolution, or chromosomal translocation. One case had a rearrangement of the bcl-1 locus and three of the bcl-2...
Topics
- Antigens, CD
- Blotting, Southern
- Chromosome Mapping
- DNA, Neoplasm
- Gene Rearrangement
- Genes, Immunoglobulin
- Genes, Retinoblastoma
- Genotype
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Oncogenes