Article
Biallelic IgH rearrangements in patients with indolent lymphoproliferative disorders: molecular and practical implications.
Journal of cellular physiology - 1 May 2004
Cerny Jan, Slavickova Alena, Krepelova Anna, Trneny Marek, Karban Josef, Klener Pavel
Abstract excerpt
We report a group of patients (pts) with indolent lymphoproliferative disorder who had both alleles for the immunoglobulin heavy chain genes rearranged (biIgH). This group of 17 pts consisted of 9 small lymphocytic lymphomas (SLL) and 8 chronic lymphocytic leukemia (CLL). The polymerase chain reaction (PCR) amplification of clonal immunoglobulin heavy (IgH) rearrangement using the complementarity determining...
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