Article
Expression of differentiation-related phenotypes and apoptosis are independently regulated during myeloid cell differentiation.
Journal of biochemistry - 1 Jan 1995
Terui Y, Furukawa Y, Sakoe K, Ohta M, Saito M
Abstract excerpt
When human promyelocytic leukemia cell line HL-60 was treated with various differentiation-inducers, apoptosis always occurred after the full appearance of differentiation-related phenotypes. However, the two phenomena could be dissociated when HL-60 cells were treated with PDBu. When HL-60 cells...
Topics
- Apoptosis
- Base Sequence
- Cell Differentiation
- Down-Regulation
- Gene Expression Regulation, Neoplastic
- Hematopoietic Stem Cells
- Humans
- Leukemia, Promyelocytic, Acute
- Molecular Sequence Data
- Nitroblue Tetrazolium
- Oligonucleotides, Antisense
- Oncogenes
- Phenotype
- Phorbol 12,13-Dibutyrate
- RNA, Messenger
- Tumor Cells, Cultured