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Article

Combined vitamin D3/retinoic acid induction of human promyelocytic cell lines: enhanced phagocytic cell maturation and hybrid granulomonocytic phenotype.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 May 1995

Masciulli R, Testa U, Barberi T, Samoggia P, Tritarelli E, Pustorino R, Mastroberardino G, Camagna A, Peschle C

Abstract excerpt

Studies on the effect of retinoic acid (RA) and 1,25-dihydroxyvitamin (D3) on the differentiation of leukemic cells have provided insight into the cellular and molecular mechanisms underlying hematopoietic cell differentiation. We have evaluated the combined effect of these chemical inducers on the differentiation of HL-60 and AML-193 promyelocytic leukemia cell lines. Simultaneous RA+D3 addition potentiated...

Topics

Antigens, CD
Cell Differentiation
Cholecalciferol
Granulocytes
Hematopoietic Stem Cells
Humans
Leukemia, Monocytic, Acute
Leukemia, Promyelocytic, Acute
Monocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phagocytes

Phenotype

Tretinoin

Tumor Cells, Cultured

Source

Identifiers

PMID: 7647032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7647032-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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