Article
No association of three GRIN2B polymorphisms with lithium response in bipolar patients.
Pharmacological reports : PR - 1 Jan 2000
Szczepankiewicz Aleksandra, Skibińska Maria, Suwalska Aleksandra, Hauser Joanna, Rybakowski Janusz K
Abstract excerpt
We investigated three polymorphisms in the NMDA receptor 2B subunit gene (GRIN2B) as a candidate gene for lithium response involved in glutamatergic neurotransmission. One hundred five bipolar patients treated with lithium for at least 5 years were analyzed. The lithium response was assessed as excellent - no affective episodes during lithium treatment; partial - 50% reduction in the episode index; or no response...
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