Article
A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.
The American journal of psychiatry - 1 Jun 2009
Perlis Roy H, Smoller Jordan W, Ferreira Manuel A R, McQuillin Andrew, Bass Nick, Lawrence Jacob, Sachs Gary S, Nimgaonkar Vishwajit, Scolnick Edward M, Gurling Hugh, Sklar Pamela, Purcell Shaun
Abstract excerpt
OBJECTIVE: Lithium remains a first-line treatment for bipolar disorder, but the mechanisms by which it prevents the recurrence of mood episodes are not known. The authors utilized data from a genomewide association study to examine associations between single nucleotide polymorphisms (SNPs) and the outcome of lithium treatment in two cohorts of patients with bipolar I disorder or bipolar II disorder. METHOD: The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.