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Article

Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response.

Pharmacogenomics - 1 Feb 2011

Hwang Rudi, Souza Renan P, Tiwari Arun K, Zai Clement C, Müller Daniel J, Potkin Steven G, Lieberman Jeffrey A, Meltze Herbert Y, Kennedy James L

Abstract excerpt

AIMS: To investigate the possible association and gene-gene interaction effects of polymorphisms in NMDA receptor subunit (GRIN1, GRIN2A and GRIN2B) and dopamine receptor (DRD1, DRD2 and DRD3) genes with clozapine response. MATERIALS & METHODS: GRIN1 rs11146020 (G1001C), GRIN2A GT-repeat and GRIN2B rs10193895 (G-200T) polymorphisms were tested for association in a Caucasian (n = 183) and an African-American (n =...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Analysis of Variance
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Share to Receptors, N-Methyl-D-Aspartate

Source

Identifiers

PMID: 21332319
DOI: 10.2217/pgs.10.182

Genes

DRD1
DRD3
GRIN1
DRD2

Variants

rs11146020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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