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Article

Influence of GRIK4 genetic variants on the electroconvulsive therapy response.

Neuroscience letters - 28 Jul 2016

Minelli Alessandra, Congiu Chiara, Ventriglia Mariacarla, Bortolomasi Marco, Bonvicini Cristian, Abate Maria, Sartori Riccardo, Gainelli Giulio, Gennarelli Massimo

Abstract excerpt

Several lines of evidence have shown the involvement of the glutamatergic system in the function of electroconvulsive therapy (ECT). In particular, patients with treatment resistant depression (TRD) and chronic depression have lower levels of glutamate/glutamine than controls, and ECT can reverse this deficit. Genetic factors might contribute to modulating the mechanisms underlying ECT. This study aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27222927
DOI: 10.1016/j.neulet.2016.05.030

Genes

GRIK4
TRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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