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Article

Genetic association analysis of N-methyl-D-aspartate receptor subunit gene GRIN2B and clinical response to clozapine.

Human psychopharmacology - 1 Mar 2016

Taylor Danielle L, Tiwari Arun K, Lieberman Jeffrey A, Potkin Steven G, Meltzer Herbert Y, Knight Jo, Remington Gary, Müller Daniel J, Kennedy James L

Abstract excerpt

OBJECTIVE: Approximately 30% of patients with schizophrenia fail to respond to antipsychotic therapy and are classified as having treatment-resistant schizophrenia. Clozapine is the most efficacious drug for treatment-resistant schizophrenia and may deliver superior therapeutic effects partly by modulating glutamate neurotransmission. Response to clozapine is highly variable and may depend on genetic factors as...

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Identifiers

PMID: 26876050
DOI: 10.1002/hup.2519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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