Article
Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: a pharmacokinetic-pharmacodynamic study.
British journal of anaesthesia - 1 Sept 2009
Ginosar Y, Davidson E M, Meroz Y, Blotnick S, Shacham M, Caraco Y
Abstract excerpt
BACKGROUND: There are diverse reports concerning the single-nucleotide polymorphism (SNP) A118G in the gene coding for the mu-opioid receptor. This study assessed pharmacokinetic-pharmacodynamic relationships in patients with acute pain (water-immersed extracorporeal shock wave lithotripsy). METHODS: Ninety-nine patients (ASA I-II, age 18-70) were assessed in this prospective observational study. Blinding was...
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