Article
Effect of μ-opioid receptor A118G polymorphism on the ED50 of epidural sufentanil for labor analgesia.
International journal of obstetric anesthesia - 1 Jan 2012
Camorcia M, Capogna G, Stirparo S, Berritta C, Blouin J L, Landau R
Abstract excerpt
BACKGROUND: A common polymorphism of the μ-opioid receptor gene (OPRM1, p.118A/G), which has been shown to effect the response to neuraxial opioids, occurs in 30% of Caucasian women. This double-blind up-down sequential allocation study was designed to examine the effect of p.118A/G on the ED50 of epidural sufentanil for labor analgesia. METHODS: Nulliparous women were recruited at 35 weeks of gestation (n=77)...
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