Article

Reelin engages non-canonical signaling pathways to drive endothelial remodeling and plasticity

2026-04-10

Abstract excerpt

<h4>BACKGROUND</h4> The vascular endothelium is a dynamic tissue central to vascular homeostasis and disease, with endothelial cells (ECs) exhibiting plasticity that drives adaptive remodeling. Reelin, a secreted extracellular matrix glycoprotein critical for neuronal migration via ApoER2/VLDLR-DAB1 signaling, may also modulate vascular function and inflammation. However, its direct role in EC biology remains unc...

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Literature Corpus work: 9331230b-4250-54f4-b474-81d3e60d4f3b
DOI: 10.64898/2026.04.08.717341

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