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Article

Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis.

Critical care (London, England) - 1 Jan 2009

Poehlmann Holger, Schefold Joerg C, Zuckermann-Becker Heidrun, Volk Hans-Dieter, Meisel Christian

Abstract excerpt

INTRODUCTION: Patients with sepsis often demonstrate severely impaired immune responses. The hallmark of this state of immunoparalysis is monocytic deactivation characterized by decreased human leukocyte antigen (HLA)-DR expression and reduced production of proinflammatory cytokines. Recently, diminished numbers of dendritic cells (DCs) were reported in patients with sepsis. However, little is known about DC...

Topics

Adult
Aged
Cytokines
Dendritic Cells
Female
Flow Cytometry
HLA-DR Antigens
Humans
Male
Middle Aged
Phenotype
Prospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sepsis

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Identifiers

PMID: 19604380
DOI: 10.1186/cc7969
PMCID: PMC2750167

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