Article

Long-term immune reprogramming of classical monocytes with altered ontogeny mediates enhanced lung injury in sepsis survivors

2025-05-21

Abstract excerpt

Patients who survive sepsis are predisposed to new hospitalizations for respiratory failure, but the underlying mechanisms are unknown. Using a murine model in which prior sepsis predisposes to enhanced lung injury, we previously discovered that classical monocytes persist in the lungs after long-term recovery from sepsis and exhibit enhanced cytokine expression after secondary challenge with intra-nasal lipopolys...

Identifiers and source

Literature Corpus work: bb9ba69e-e388-5f7d-afa0-5744b6f90a15
DOI: 10.1101/2025.05.16.654442

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