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Article

Dynamic changes in human HLA‐DRA gene expression and Th cell subsets in sepsis: Indications of immunosuppression and associated outcomes

6 Aug 2019

Abstract excerpt

BACKGROUND: Sepsis is a life-threatening disease that is an immune disorder response that causes multiple organ dysfunction. In this study, we investigated the dynamic changes in mRNA expression of HLA-DRA gene and the specific transcription factor of helper T cell subsets to explore long-term immunophenotyping and its relationship with prognosis. METHODS: Seventy-eight sepsis patients and twelve healthy controls...

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PMID: 31386235
DOI: 10.1111/sji.12813

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