Article
T cells from patients with Candida sepsis display a suppressive immunophenotype.
Critical care (London, England) - 20 Jan 2016
Spec Andrej, Shindo Yuichiro, Burnham Carey-Ann D, Wilson Strother, Ablordeppey Enyo A, Beiter Evan R, Chang Katherine, Drewry Anne M, Hotchkiss Richard S
Abstract excerpt
BACKGROUND: Despite appropriate therapy, Candida bloodstream infections are associated with a mortality rate of approximately 40%. In animal models, impaired immunity due to T cell exhaustion has been implicated in fungal sepsis mortality. The purpose of this study was to determine potential mechanisms of fungal-induced immunosuppression via immunophenotyping of circulating T lymphocytes from patients with...
Topics
- Adult
- Aged
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Candida
- Candidemia
- Female
- Humans
- Immunosuppression Therapy
- Male
- Middle Aged
- Phenotype
- Prospective Studies